Synthesis of the C15-C35 northern hemisphere subunit of the chivosazoles |
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| Authors: | Paterson Ian Gibson Lisa J Kan S B Jennifer |
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| Institution: | University Chemical Laboratory, Lensfield Road, Cambridge, CB2 1EW, UK. ip100@cam.ac.uk |
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| Abstract: | An advanced C15-C35 subunit of the chivosazole polyene macrolides was prepared in a convergent manner, exploiting boron-mediated aldol reactions for the stereocontrolled construction of the C15-C26 and C27-C35 segments, followed by their Pd/Cu-promoted Stille coupling to configure the signature (23E,25E,27Z)-triene motif. Correlation with a known C28-C35 degradation fragment of chivosazole A was also achieved. |
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