Nitration of 3-Methylaceperidazines with a Large Excess of Fuming Nitric Acid |
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| Authors: | N I Omelichkin L G Minyaeva A A Milov L G Kuz’mina V V Mezheritskii |
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| Institution: | 1.Research Institute of Physical and Organic Chemistry,Southern Federal University,Rostov-on-Don,Russia;2.Southern Scientific Center of the Russian Academy of Sciences,Rostov-on-Don,Russia;3.Institute of General and Inorganic Chemistry of the Russian Academy of Sciences,Moscow,Russia |
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| Abstract: | Nitration of N-acetyl-3-methylaceperidazine with a 2–3-fold excess of nitric acid (d 1.36, 1.48) in glacial acetic acid results in the exclusive formation of mono- and dinitroderivatives. The nitration of 3-methylaceperidazine and its N-alkyl- and N-acetyl-substituted derivatives with a 6–9-fold excess of fuming nitric acid (d 1.54) in the same conditions results in the formation of both the expected products of mono- and dinitration and a product of the electrophilic addition of nitric acid to a double bond of acenaphthene scaffold of the molecule of nitration product. |
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