A new copper acetate-bis(oxazoline)-catalyzed, enantioselective Henry reaction |
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| Authors: | Evans David A Seidel Daniel Rueping Magnus Lam Hon Wai Shaw Jared T Downey C Wade |
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| Institution: | Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA. evans@chemistry.harvard.edu |
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| Abstract: | A highly enantioselective, nitroaldol reaction catalyzed by a chiral Cu(II) bis(oxazoline) complex has been developed. The reaction scope includes both aromatic and aliphatic aldehydes (15 examples) affording products in good yields and enantioselectivities (87-94% ee). An X-ray structure of the catalyst has been provided along with a rationalization of the sense of asymmetric induction. |
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