Synthesis,thermo-responsive micellization and caffeine drug release of novel PBMA-<Emphasis Type="Italic">b</Emphasis>-PNIPAAm block polymer brushes |
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Authors: | Yan-Ling Luo Li-Li Zhang Feng Xu |
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Institution: | 1.Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry and Materials Science,Shaanxi Normal University,Xi’an,China |
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Abstract: | Brush-like block copolymers with poly(t-butyl methacrylate) (PBMA) and poly(N-isopropylacrylamide) (PNIPAAm) as side arms, PBMA-b-PNIPAAm, were designed and synthesized via a simple free radical polymerization route. The chemical structure and molecular
weight of these polymer brushes were characterized and determined by nuclear magnetic resonance (1H NMR), Fourier transform infrared spectrometry (FTIR) and gel permeation chromatography (GPC). The micellar formation by
these polymer brushes in aqueous solutions were detected by a surface tension technique, and the critical micelle concentration
(CMC) ranged from 1.53 to 8.06 mg L−1. The morphology and geometry of polymer micelles were investigated by transmission electron microscope (TEM) and dynamic
light scattering (DLS). The polymer micelles assume the regularly-spherical core-shell structure with well-dispersed individual
nanoparticles, and the particle size was in the range from 36 to 93 nm. The PNIPAAm segments exhibited a thermoreversible
phase transition, so the resulting block polymer brushes were temperature-sensitive and the low critical solution temperature
(LCST) was determined by UV-vis spectrometer at about 28.82–29.40°C. The characteristic parameters of the polymer micelles
such as CMC, micellar size and LCST values were affected by their compositional ratios and the length of hydrophilic or hydrophobic
chains. The evaluation for caffeine drug release behavior of the block polymer micelles demonstrated that the self-assembled
micelles exhibited thermal-triggered properties in controlled drug release. |
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