Multiplex cancer cell detection by SERS nanotags with cyanine and triphenylmethine Raman reporters |
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| Authors: | Maiti Kaustabh Kumar Samanta Animesh Vendrell Marc Soh Kiat-Seng Olivo Malini Chang Young-Tae |
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| Institution: | Singapore Bioimaging Consortium, Agency for Science, Technology and Research, 11 Biopolis Way, 138667 Singapore. |
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| Abstract: | SERS nanotags have been prepared to accomplish the multiplex detection of cancer cells. Herein we evaluated the adequacy of lipoic acid-containing cyanine derivatives (Cy3LA and Cy5LA) to function as multiplex partners with a triphenylmethine Raman reporter (B2LA) under a single excitation wavelength. SERS experiments enabled the multiplex recognition of two different cancer cells with antibody-conjugated nanotags that were derivatized with optimized cyanine and triphenylmethine reporters. |
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