A novel synthesis of 5-fluorouracil derivatives having oxacycloalkane moieties |
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| Authors: | Tameo Iwasaki Takashi Nishitani Hiroshi Horikawa Ichizo Inoue |
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| Institution: | Department of Synthetic Chemistry, Research Laboratory of Applied Biochemistry, Tanabe Seiyaku Co. Ltd., Kashima-3-chome, Yodogawa-ku, Osaka 552, Japan |
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| Abstract: | 5-Fluorouracil derivatives having oxacycloalkane moieties were synthesized in good yields by the reaction of trimethylsilyloxyalkanal dialkyl acetals with 2,4-bis(trimethylsilyl)-5-fluorouracil in the presence of SnCl4. |
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