首页 | 本学科首页   官方微博 | 高级检索  
     


Total synthesis of (+)-prelog-djerassi lactonic acid
Authors:Minoru Isobe  Yoshiyasu Ichikawa  Toshio Goto
Affiliation:Laboratory of Organic Chemistry, Faculty of Agriculture, Nagoya University, Chikusa, Nagoya 464, Japan
Abstract:Optically active Prelog-Djerassi Lactonic Acid 1 was synthesized from D-glucal: the crucial point being the elaboration of the carboxylic group as shown in eq. 1 and 2 which involve the sequential process [i] asymmetric addition of methyl anion onto the hetero-olefin 2, [ii] trapping the carbanion intermediate 3 [E=Li to SePh] and [iii] oxidative hydrolysis of 3via sila-pummerer rearrangement into 4.
Keywords:
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号