The protection of uracil and guanine residues in oligonucleotide synthesis |
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Authors: | Simon S. Jones Colin B. Reese Samson Sibanda Aiko Ubasawa |
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Affiliation: | Department of Chemistry, King''s College, Strand, London WC2R 2LS, England |
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Abstract: | The protection of uracil and 2--acyl guanine residues with 4--phenyl [or 4--(2,4-dimethylphenyl)] and 6--(2-nitrophenyl) groups as in [or ] and , respectively, is described. These -aryl protecting groups, which appear to withstand the usual conditions of oligonucleotide synthesis, may readily be removed by treatment with 2-nitrobenzaldoximate ions. |
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