Antiviral Activities of Photoactive Perylenequinones |
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Authors: | J B Hudson V Imperial R P Haugland Z Diwu |
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Institution: | Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada;Department of Botany, University of British Columbia, Vancouver, BC, Canada;Molecular Probes Inc., Eugene, OR USA |
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Abstract: | Nine perylenequinones (PQ), including some familiar naturally occurring pigments, were compared for their light-mediated antiviral efficacies. Calphostin C was the most active compound against the two target viruses, herpes simplex virus type 1 and Sindbis virus. Hypo-crellins A and B were also very active. However, three cercosporin-like PQ were substantially less active in spite of their high quantum yields of singlet oxygen, whereas phleichrome, another efficient singlet oxygen producer, showed no detectable antiviral activity. One other PQ, which was a very weak singlet oxygen producer, also showed no antiviral activity. None of the active compounds showed significant antiviral activity in the dark. Thus, for some groups of PQ there was correlation between quantum yield of singlet oxygen C02) and antiviral efficacy, but there are evidently other structural features of PQ that influence activity. |
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