Optimal control of bioprocess systems using hybrid numerical optimization algorithms

In the paper, we consider the bioprocess system optimal control problem. Generally speaking, it is very difficult to solve this problem analytically. To obtain the numerical solution, the problem is transformed into a parameter optimization problem with some variable bounds, which can be efficiently solved using any conventional optimization algorithms, e.g. the improved Broyden–Fletcher–Goldfarb–Shanno algorithm. However, in spite of the improved Broyden–Fletcher–Goldfarb–Shanno algorithm is very efficient for local search, the solution obtained is usually a local extremum for non-convex optimal control problems. In order to escape from the local extremum, we develop a novel stochastic search method. By performing a large amount of numerical experiments, we find that the novel stochastic search method is excellent in exploration, while bad in exploitation. In order to improve the exploitation, we propose a hybrid numerical optimization algorithm to solve the problem based on the novel stochastic search method and the improved Broyden–Fletcher–Goldfarb–Shanno algorithm. Convergence results indicate that any global optimal solution of the approximate problem is also a global optimal solution of the original problem. Finally, two bioprocess system optimal control problems illustrate that the hybrid numerical optimization algorithm proposed by us is low time-consuming and obtains a better cost function value than the existing approaches.