Tandem Molecular Self‐Assembly in Liver Cancer Cells |
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Authors: | Jie Zhan Yanbin Cai Shuangshuang He Prof Ling Wang Prof Zhimou Yang |
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Institution: | 1. State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China;2. College of Life Sciences, Key Laboratory of Bioactive Materials, Ministry of Education, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin, China |
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Abstract: | We herein describe the tandem molecular self‐assembly of a peptide derivative ( 1 ) that is controlled by a combination of enzymatic and chemical reactions. In phosphate‐buffered saline (PBS), compound 1 self‐assembles first into nanoparticles by phosphatase and then into nanofibers by glutathione. Liver cancer cells exhibit higher concentrations of both phosphatase and GSH than normal cells. Therefore, the tandem self‐assembly of 1 also occurs in the liver cancer cell lines HepG2 and QGY7703; compound 1 first forms nanoparticles around the cells and then forms nanofibers inside the cells. Owing to this self‐assembly mechanism, compound 1 exhibits large ratios for cellular uptake and inhibition of cell viability between liver cancer cells and normal liver cells. We envision that using both extracellular and intracellular reactions to trigger tandem molecular self‐assembly could lead to the development of supramolecular nanomaterials with improved performance in cancer diagnostics and therapy. |
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Keywords: | cancer fluorescence hydrogels nanofibers self-assembly |
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