| 海藻酸盐凝胶化及其在软骨组织工程和药物控释领域的应用（专题报道） |
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| 引用本文： | 鲁路,刘新星,童真. 海藻酸盐凝胶化及其在软骨组织工程和药物控释领域的应用（专题报道）[J]. 高分子学报, 2010, 0(12): 1351-1358. DOI: 10.3724/SP.J.1105.2010.10221 |
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| 作者姓名： | 鲁路 刘新星 童真 |
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| 作者单位： | 暨南大学材料科学与工程系 广州 510632; 华南理工大学材料科学研究所 广州 510640 |
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| 摘 要： | 介绍了海藻酸盐水溶液的凝胶化及其临界行为和松弛临界指数n.提出了将凝胶化按高分子的分子链长短分为生长型和交联型两类，前者为无规交联，符合逾渗连接的条件；后者大分子链间交联，不符合无规逾渗连接的条件.介绍了微囊化细胞载体、预成型支架和可注射支架，能够为软骨细胞提供良好的三维生长环境；通过LbL、二价离子交联等自组装技术，海藻酸能够实现对多种类型药物的包埋和控释.
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| 关 键 词： | 海藻酸盐 凝胶化 组织工程 软骨 药物控释 |
| 收稿时间： | 2010-07-13 |
GELATION IN ALGINATE SOLUTIONS AND ITS APPLICATIONS IN CARTILAGE TISSUE-ENGINEERING AND DRUG CONTROLLED RELEASE (Special Topic) |
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| LU Lu,LIU Xin-Xing,TONG Zhen. GELATION IN ALGINATE SOLUTIONS AND ITS APPLICATIONS IN CARTILAGE TISSUE-ENGINEERING AND DRUG CONTROLLED RELEASE (Special Topic)[J]. Acta Polymerica Sinica, 2010, 0(12): 1351-1358. DOI: 10.3724/SP.J.1105.2010.10221 |
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| Authors: | LU Lu LIU Xin-Xing TONG Zhen |
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| Affiliation: | Department of Materials Science and Engineering, Jinan University, Guangzhou 510632; Research Institute of Materials Science, South China University of Technology, Guangzhou 510640 |
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| Abstract: | Alginate possesses many favorable properties required for biomaterials such as biocompatibility and gelation under gentle conditions.The critical behaviour of the sol-gel transition in aqueous alginate solutions induced by cations was affected by many factors, including the molecular weight and molecular structure sequence of alginate and the kind of cations.The critical exponents suggested two categories of the gelation as growth and crosslink according to molecular size in the solution just before the gelation.Alginate is widely used in tissue-engineered cartilages and drug controlled release.This review seeks to condense information in developing materials for these applications. |
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| Keywords: | Alginate Gelation Tissue engineering Cartilage Drug controlled release |
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