Chemoselective hydrogenation of nitriles to primary amines catalyzed by water‐soluble transition metal catalysts |
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| Authors: | Abdelaziz Nait Ajjou André Robichaud |
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| Institution: | 1. Department of Chemistry and Biochemistry, Université de Moncton, Moncton, New‐Brunswick, Canada;2. Health Canada, Longueuil, Québec, Canada |
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| Abstract: | The water‐soluble rhodium complex generated in situ from Rh (COD)Cl]2 in aqueous ammonia has been revealed as a highly efficient catalyst for the hydrogenation of aromatic nitriles, to primary amines with excellent yields. The catalyst is also highly selective towards primary amines in the case of sterically hindered aliphatic nitriles. The catalytic system can also be recycled and re‐used with no significant loss of activity. |
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| Keywords: | aqueous ammonia hydrogenation nitriles primary amines water‐soluble catalysts |
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