Synthesis of New Spiro-Cyclopropanes Prepared by Non-Stabilized Diazoalkane Exhibiting an Extremely High Insecticidal Activity |
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| Authors: | Naoufel Ben Hamadi Ahlem Guesmi |
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| Affiliation: | 1.Chemistry Department, College of Science, IMSIU (Imam Mohammad Ibn Saud Islamic University), P.O. Box 5701, Riyadh 11432, Saudi Arabia;2.Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11ES39), Faculty of Science of Monastir, UM (University of Monastir), Avenue of Environment, Monastir 5019, Tunisia;3.Textile Engineering Laboratory, Higher Institute of Technological Studies of Ksar Hellal, UM (University of Monastir), Monastir 5000, Tunisia |
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| Abstract: | The synthesis of new insecticidal gem-dimethyspiro-cyclopropanes derived from pyrrolidine-2,3-dione have been described, and their biological effect against different insect species has been evaluated. The presented results demonstrate the excellent insecticidal activity of cyclopropane 5c against Aedes aegypti and Musca domestica. Cyclopropane 5c showed the quickest knockdown and the best killing against Aedes aegypti and Musca domestica compared to trans-chrysanthemic acid and pyrethrin. The biological results of the high insecticidal activity were confirmed by the results of docking. This is evident in the binding affinity obtained for cyclopropane 5c, indicating good binding with an important active amino acid residue of the 5FT3 protein. |
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| Keywords: | 1,3-dipolar cycloaddition photolysis 1H-pyrazole spiro-cyclopropane docking insecticides |
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