| DNA光复活作用机理的研究进展* |
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| 引用本文： | 宋钦华,郭庆祥. DNA光复活作用机理的研究进展*[J]. 化学进展, 2001, 13(6): 428-435 |
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| 作者姓名： | 宋钦华 郭庆祥 |
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| 作者单位： | 中国科学技术大学化学系 合肥 230026 |
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| 基金项目： | 国家自然科学基金 (批准号 :30 0 0 0 0 36 ),中国科学技术大学青年科学基金资助项目 |
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| 摘 要： | "环丁烷型嘧啶二聚体(Pyr< > Pyr) 是太阳光中紫外线造成DNA 损伤的主要光化学产物。DNA 光复活酶(或称光解酶) 能够利用可见光裂解二聚体的环丁烷环而修复DNA。本文对DNA 光复活过程中的光解酶对Pyr< > Pyr 的识别和光催化Pyr< > Pyr 裂解反应进行了综述, 介绍了DNA 光解酶的结构、DNA 的主要UV 光化学产物。较详尽地评述了国际上在光解酶催化二聚体裂解的途径以及模型研究方面的最新进展, 并预测了该领域的发展前景。
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| 关 键 词： | 光复活作用 DNA光解酶 环丁烷型嘧啶二聚体 分子识别 光修复作用 |
| 文章编号： | 1005-281X(2001)06-0428-08 |
| 收稿时间： | 2000-09-01 |
| 修稿时间： | 2000-09-01 |
Recent Progress in Studies of Mechanism for DNA Photoreactivation |
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| Song Qinhua,Guo Qingxiang. Recent Progress in Studies of Mechanism for DNA Photoreactivation[J]. Progress in Chemistry, 2001, 13(6): 428-435 |
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| Authors: | Song Qinhua Guo Qingxiang |
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| Affiliation: | Department of Chemistry, University of Science and Technology of China, Hefei 230026, China |
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| Abstract: | Cyclobutane pyrimidine dimers (Pyr<>Pyr) are the major DNA photoproducts induced by the UV radiation. Photoreactivating enzyme (DNA photolyase) repairs DNA by utilizing the energy of visible light to break the cyclobutane ring of the dimer. In this paper, binding and splitting mechanism of pyrimidine dimer by DNA photolyase were reviewed. The structure of DNA photolyases and the UV induced DNA photoproducts were introduced. In particular, recent research progress in photorepair mechanism of the photolyase was discussed. |
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| Keywords: | photoreactivation DNA photolyase cyclobutane pyrimidine dimer molecular recognition photorepair |
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