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胺解改性聚L-谷氨酸苄酯引导骨再生膜的制备
引用本文:陆嘉玮,张坤玺,虞玺,颜世峰,尹静波. 胺解改性聚L-谷氨酸苄酯引导骨再生膜的制备[J]. 高等学校化学学报, 2019, 40(3): 601. DOI: 10.7503/cjcu20180354
作者姓名:陆嘉玮  张坤玺  虞玺  颜世峰  尹静波
作者单位:上海大学材料科学与工程学院高分子材料系,上海,200444;上海大学材料科学与工程学院高分子材料系,上海,200444;上海大学材料科学与工程学院高分子材料系,上海,200444;上海大学材料科学与工程学院高分子材料系,上海,200444;上海大学材料科学与工程学院高分子材料系,上海,200444
基金项目:国家自然科学基金(批准号: 51773113)资助.
摘    要:以聚L-谷氨酸苄酯(PBLG)为原料, 通过溶剂浇铸与粒子沥滤法分别构建PBLG单层致密和PBLG单层多孔膜, 利用乙醇胺对薄膜表面改性, 构筑双层引导骨再生膜. 研究了不同胺解改性时间对PBLG-s-PHEG双层膜亲水性和力学性能的影响, 结果表明, 随着PBLG分子量的增大, 薄膜的力学性能增强而降解速率减缓. 延长胺解改性时间可提高薄膜亲水性和体内外降解速率. 细胞实验结果表明, 双层薄膜的致密结构能够有效阻隔成纤维细胞的侵入, 多孔结构能够支持细胞贴壁黏附和铺展. 体外生物活性评价结果表明, 表面改性的PBLG基材料可用于体内骨缺损修复. 本文所构建的双层引导骨再生膜在体外具有良好的力学性能和降解性能, 与组织具有一定的贴合性, 同时可有效阻碍成纤维细胞侵入, 具有潜在应用价值.

关 键 词:聚L-谷氨酸苄酯  乙醇胺解  引导骨再生膜
收稿时间:2019-05-11

Preparation of Amine-modified Poly(γ-benzyl-L-glutamate) Guided Bone Regeneration Film†
LU Jiawei,ZHANG Kunxi,YU Xi,YAN Shifeng,YIN Jingbo. Preparation of Amine-modified Poly(γ-benzyl-L-glutamate) Guided Bone Regeneration Film†[J]. Chemical Research In Chinese Universities, 2019, 40(3): 601. DOI: 10.7503/cjcu20180354
Authors:LU Jiawei  ZHANG Kunxi  YU Xi  YAN Shifeng  YIN Jingbo
Affiliation:Department of Polymer Materials, School of Matrials Science and Engineering,Shanghai University, Shanghai 201800, China
Abstract:Guided bone regeneration film plays an important role in bone defect reconstruction. In this paper, poly(γ-benzyl-L-glutamate)(PBLG) was used as raw materials to construct dense films and porous films by solvent casting and particle leaching. And the bilayers guided bone regeneration membrane was constructed by ethanolamine amine membrane modification on the surface. The effect of different modification time on the hydrophilicity and mechanical properties of the films was investigated. The results show that with the increase of the molecular weight of PBLG, the mechanical strength of the film increases and the degradation rate is getting slower. Prolonging the time of amine modification can improve the hydrophilicity of the film and the degradation rate both in vivo and in vitro. Through cell experiments, it was found that the dense layer could effectively block the invasion of fibroblasts, and the porous layer can support adherence and spread of cells. Surface-modified PBLG-based materials were demonstrated to be useful for repair of bone defects in vivo by in vitro bioactivity evaluation. The guided bone regeneration membrane constructed has good mechanical properties, degradation performance, and a certain degree of fit with the tissue. And it could effectively inhibit the infiltration of fibroblasts. The membrane has potential application value.
Keywords:Poly(γ-benzyl-L-glutamate)(PBLG)  ,Ethanolamine ammonolysis,Guided bone regeneration,
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