细菌环二鸟苷酸介导的信号转导途径研究进展

环二鸟苷酸(c-di-GMP)是在细菌中广泛存在的第二信使分子,它介导的信号转导途径涉及调控细菌的运动、致病性、生物膜形成、细胞周期进程和有机溶剂耐受性等多种重要功能.该文主要从c-di-GMP的合成与降解、c-di-GMP的效应子及c-di-GMP的生理作用3方面对c-di-GMP介导的信号转导途径进行总结,并对该信号转导途径的研究前景进行了展望.

The Advance in Signaling Pathway Mediated by Cyclic Diguanosine Monophosphate in Bacteria

Cyclic diguanosine monophosphate(c-di-GMP)is one of second messengers,which is widely existed in bacteria.The signaling pathway mediated by c-di-GMP is involved in the regulation of various important functions in bacteria including motility,virulence,biofilm formation,cell cycle and organic solvents tolerance.In the present paper,the synthesis and degradation of c-di-GMP,the effectors of c-di-GMP and the physiological roles of c-di-GMP are summarized and the outlook in the signaling pathway research is presented.