B(C6 F5)3催化吲哚与苯乙炔的区域选择性加成

使用B（C₆F₅）₃替代稀有金属催化剂，实现了绿色、无毒、温和催化吲哚与苯乙炔的加成反应.对吲哚不同位置带有取代基的底物进行拓展，在室温条件下高产率获得了一系列双吲哚烷烃.对机理的初步探究表明，反应首先从苯乙炔被B（C₆F₅）₃活化开始，而后依次受到两分子吲哚进攻，经马氏加成得到相应产物.根据探究结果，给出了可能的反应机理.

Metal-free B(C6F5)3 Catalyzed Regioselective Addition of Indole to Phenylacetylene

Catalytic amounts of B (C₆F₅)₃ was found to be able to catalyze the highly regioselective addition of various indoles to phenylacetylene,and produced different substituted bisindolylmethanes in high yields at room temperature.Contrast to the traditional catalysts such as In,Pt and Ru,B (C₆F₅)₃ finished the reaction under green and mild catalytic conditions with high atom economical and good functional group tolerance.Under the optimization reaction conditions,near quantitative conversions and up to 92% yields of bisindolylmethanes were achieved.According to the separated byproduct 4a' and the observed intermediates Ⅰ,a possible reaction mechanism based on the mechanistic studies has been proposed.The reaction was initiated from the activation of phenylacetylene by B (C₆F₅)₃ and ended with the addition of two molecules indoles one by one to the phenylacetylene.The further applied value research of bisindolylmethanes is in progress.