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Three new ingol diterpenes from Euphorbia nivulia: evaluation of cytotoxic activity |
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| Authors: | Ravikanth Veluri Lakshmi Niranjan Reddy Vanimireddy Vijender Reddy Adelli Ravinder Kodela Prabhakar Rao Tadikamalla Siva Ram Tejomoorty Anand Kumar Kondapi Prakesh Vamanarao Diwan Venkateswarlu Yenamandra |
| Affiliation: | Pharmacology Division, Indian Institute of Chemical Technology, Hyderabad-500 007, India. |
| Abstract: | The latex of Euphorbia nivulia afforded three new ingol diterpenes, 3-acetyl-8-methoxyl-7-angolyl-12-hydroxylingol (7), 3,12-diacetyl-7-hydroxy-8-methoxylingol (8), and 3,12-diacetyl-7-angolyl-8-hydroxylingol (9) along with five known ingol diterpenes 2-6 and a known triterpene cyclonivulinol (1). Their structures were established by means of spectroscopic analysis. Diterpenes 2-9 were evaluated for their cytotoxic activity. |
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