An efficient one-step synthesis of 2-arylquinolin-4(1H)-ones with the aid of a low-valent titanium reagent |
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| Authors: | Fang SunXuan Zhao Daqing Shi |
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| Affiliation: | Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China |
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| Abstract: | A short and facile synthesis of a series of 2-arylquinolin-4(1H)-ones was accomplished in good yields via the novel reductive cyclization of 2-nitrochalcones promoted by TiCl4/Zn. This method has the advantages of accessible starting materials, one-step procedure, convenient manipulation, and moderate to high yields. |
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| Keywords: | Low-valent titanium Cyclization Quinolin-4(1H)-one |
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