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Palladium(II)-catalyzed oxidative Heck coupling of thiazole-4-carboxylates |
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| Authors: | Ziyuan Li Ling Ma Changhua Tang Jinyi XuXiaoming Wu Hequan Yao |
| Institution: | a Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China b Center for Drug Discovery, China Pharmaceutical University, Nanjing 210009, PR China c State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, PR China |
| Abstract: | Oxidative Heck coupling of thiazole-4-carboxylates via palladium(II)-catalyzed C-H bond activation has been achieved in moderate to good yields. No ligand, and no acidic additive were used in the reaction. The results showed that this protocol tolerated a series of substitutions on the thiazole ring. A preliminary attempt of direct arylation with p-xylene via Pd(II)-catalyzed C-H bond activation has also been done. |
| Keywords: | Thiazole-4-carboxylate C-H bond activation Oxidative Heck-coupling Alkenylation Direct arylation |
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