Chemistry Department, The University of Manchester Institute of Science and Technology, Manchester M6O 1QD Great Britain
Abstract:
Treatment of the Grignard reagent derived from the bromo-compound (III) with dimethyl formamide affords the corresponding aldehyde (IV) which undergoes ready condensation with nitroethane to give the nitropropene (V). Reduction of compound (V) with an excess of lithium aluminium hydride gives the amphetamine (VI) in reasonable yield.
