The effect of two electron-withdrawing groups on remote tertiary hydrogens susceptible to electrophilic fluorination using F2 |
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Authors: | Chava Gal Shlomo Rozen |
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Institution: | Chemistry Department, Tel Aviv University, Tel Aviv 69978, Israel |
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Abstract: | The direct electrophilic fluorination of unactivated remote tertiary hydrogens is effected by the number, nature and distance of electron-withdrawing groups. The effect of these groups on reducing electron density of the tertiary CH bond seems to be additive. The more remote these groups are from the reaction center, the higher the yield of the fluorination. |
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