Alkaline hydrolysis of 2-(trifluoromethyl)imidazo[4,5-] and -[4,5-]quinolines |
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Authors: | Ian G. Moores Robert K. Smalley Hans Suschitzky |
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Affiliation: | The Ramage Laboratories, Department of Chemistry and Applied Chemistry, University of Salford, Salford M5 4WT Great Britain |
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Abstract: | 2-(Trifluoromethyl)imidazo[4,5-] and -[4,5-]quinoline have been prepared from 5(6),acetamido-2-(trifluoromethyl)benzimidazole and 7,8-diaminoquinoline respectively. These (trifluoromethyl)- quinolines like 2-(trifluoromethyl)imidazoles but unlike 2-(trifluoromethyl) benzimidazoles, undergo hydrolysis in dilute sodium hydroxide to give ultimately the corresponding imidazo[4,5-] and -[4,5-]- quinoline, respectively. |
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