Transition metal-catalyzed orthogonal solid-phase decoration of the 2(1H)-pyrazinone scaffold using a sulfur linker |
| |
| Authors: | Kaval Nadya Singh Brajendra Kumar Ermolat'ev Denis S Claerhout Stijn Parmar Virinder S der Eycken Johan Van der Eycken Erik Van |
| |
| Affiliation: | Laboratory for Organic & Microwave-Assisted Chemistry, Department of Chemistry, University of Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium. |
| |
| Abstract: | A new transition metal-catalyzed orthogonal solid-phase protocol for the synthesis of highly substituted 2(1H)-pyrazinones was developed, on the basis of Chan-Lam arylation and Liebeskind-Srogl cross-coupling reactions. This strategy opens the way for the generation of small libraries of 2(1H)-pyrazinone analogues for biological screening. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
