One-step controlled precipitation to fabricate glucose-responsive microcapsules |
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Authors: | Weijun?Tong Yi?Zhu Email author" target="_blank">Changyou?GaoEmail author |
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Institution: | (1) MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China; |
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Abstract: | Advanced multi-compartmental concanavalin A (Con A)/glycogen complex microcapsules incorporated with polymeric micelles were
successfully fabricated by a facile, one-step controlled precipitation method. Dropwise addition of Con A solution into glycogen
solution results in Con A/glycogen complex precipitates, which are captured by polyethyleneimine-modified CaCO3 microparticles, forming a continuous shell structure. Removal of the carbonate cores yields hollow capsules of Con A/glycogen
complex, which have variable sizes and wall thicknesses under different precipitation conditions. The capsules show molecular-recognizable
response to glucose and dextran (M
w, 20 and 40 kDa), leading to breakdown of the capsule structure and release of the incorporated substances such as poly(styrene-b-acrylic acid) micelles. |
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Keywords: | |
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