Ultrasound-assisted rapid synthesis of <Emphasis Type="Italic">β</Emphasis>-aminoketones with direct-type catalytic Mannich reaction using bismuth(III) triflate in aqueous media at room temperature |
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Authors: | S Arda Ozturkcan Kadir Turhan Zuhal Turgut |
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Institution: | (1) Chemistry and Chemical Engineering Research Center of Iran, P.O. Box 14335-186, Tehran, Iran |
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Abstract: | An innovative, powerful, efficient and relatively rapid method was developed to synthesise various β-aminoketone derivatives from cyclohexanone, substituted aromatic amines and aromatic or hetero-aromatic aldehydes via ultrasound-assisted
direct-type catalytic Mannich reaction using bismuth(III) triflate in water. Good yields of the desired β-aminoketones were obtained at room temperature by ultrasound-assisted reaction within 1–2 h. The major advantages of the
proposed method are undemanding conditions, easy operation, low toxicity, shorter reaction time, anti selectivity and higher
yields in comparison with conventional methods. |
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Keywords: | |
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