Tedanolide C: a potent new 18-membered-ring cytotoxic macrolide isolated from the Papua New Guinea marine sponge Ircinia sp |
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Authors: | Chevallier Camille Bugni Tim S Feng Xidong Harper Mary Kay Orendt Anita M Ireland Chris M |
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Institution: | Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA. |
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Abstract: | Cytotoxicity-guided fractionation of the crude methanol extract of a marine sponge, Ircinia sp., yielded tedanolide C (1), a new 18-membered macrolide. The structure was solved by interpreting NMR and MS data, and the relative stereochemistry was determined from a combination of homo- and heteronuclear coupling constants in conjunction with molecular modeling. Compound 1 exhibited potent cytotoxicity against HCT-116 cells in vitro. Cell cycle analysis showed that treatment of cells with compound 1 arrested cells in the S-phase. |
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