The total synthesis of roquefortine C and a rationale for the thermodynamic stability of isoroquefortine C over roquefortine C |
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| Authors: | Shangguan Ning Hehre Warren J Ohlinger William S Beavers Mary Pat Joullié Madeleine M |
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| Institution: | Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, USA. |
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| Abstract: | The first total synthesis of roquefortine C is achieved by implementation of a novel elimination strategy to construct the thermodynamically unstable E-dehydrohistidine moiety. Molecular modeling studies are presented which explain the instability of the roquefortine C structure compared to that of isoroquefortine C. |
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