Poly(ether ester amide) microspheres for protein delivery: influence of copolymer composition on technological and biological properties |
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| Authors: | Ostacolo Luisanna Russo Paola De Rosa Giuseppe La Rotonda Maria Immacolata Maglio Giovanni Nese Giuseppe Spagnuolo Gianrico Rengo Sandro Oliva Adriana Quaglia Fabiana |
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| Affiliation: | Department of Pharmaceutical and Toxicological Chemistry, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy. |
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| Abstract: | The production of PEEA microspheres with potential as carriers for protein oral delivery is described. PEEAs with different hydrophilicity were synthesized and characterized. Experiments showed that an increase in copolymer hydrophilicity gave particles less prone to cell interaction. BSA release profiles from PEEA microspheres demonstrated that an increase in polymer hydrophilicity was useful in limiting protein burst and modulating drug delivery rate by increasing PEEA degradability. These results show that fine-tuning of the hydrophilic/hydrophobic properties of PCL is essential for the formulation protein-loaded microspheres with specific properties. |
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| Keywords: | poly(ε‐caprolactone) microspheres proteins |
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