| The Role of Acetylcholine in the Cognitive Function of Frontal Neurons in Monkeys |
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| 引用本文： | 刘觐龙,宿双宁. The Role of Acetylcholine in the Cognitive Function of Frontal Neurons in Monkeys[J]. 中国科学B辑(英文版), 1993, 0(12) |
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| 作者姓名： | 刘觐龙 宿双宁 |
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| 作者单位： | Institute of Space Medico-Engineering，Beijing 100094，PRC，Institute of Space Medico-Engineering，Beijing 100094，PRC |
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| 基金项目： | This work was supported by the National Natural Science Foundation of China. |
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| 摘 要： | To study the role of acetylcholine(ACh) in the cognitive function of frontal lobes, ACh and atropine were applied iontophoretically to the task-related neurons recorded from an area around the superior ramus of arcuate sulcus in the frontal cortex of 4 rhesus monkeys during the performance of two tasks. The spontaneous discharges and taskrelated responses of most of the neurons which increased their discharge rate in the delay and differentiation periods of the discrimination response go/no-go task and in the cue and delay periods of the delayed discrimination go/no-go task, were further increased during the application of ACh and suppressed during atropine. These results suggest that ACh may be involved in the excitatory process of the activity of the neurons in the above-mentioned area of frontal cortex to play an important role in the cognitive functions of attention, discrimination and short-term memory.
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The Role of Acetylcholine in the Cognitive Function of Frontal Neurons in Monkeys |
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| LIU Jin-Long and SU Shuang-Ning. The Role of Acetylcholine in the Cognitive Function of Frontal Neurons in Monkeys[J]. Science in China(Chemistry), 1993, 0(12) |
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| Authors: | LIU Jin-Long and SU Shuang-Ning |
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| Abstract: | To study the role of acetylcholine(ACh) in the cognitive function of frontal lobes, ACh and atropine were applied iontophoretically to the task-related neurons recorded from an area around the superior ramus of arcuate sulcus in the frontal cortex of 4 rhesus monkeys during the performance of two tasks. The spontaneous discharges and taskrelated responses of most of the neurons which increased their discharge rate in the delay and differentiation periods of the discrimination response go/no-go task and in the cue and delay periods of the delayed discrimination go/no-go task, were further increased during the application of ACh and suppressed during atropine. These results suggest that ACh may be involved in the excitatory process of the activity of the neurons in the above-mentioned area of frontal cortex to play an important role in the cognitive functions of attention, discrimination and short-term memory. |
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| Keywords: | rhesus monkey frontal cortex mieroiontophoresis aeetyleholine discrimination task. |
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