Development of a stepwise [3 + 3] annelation to functionalized piperidines |
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| Authors: | Goodenough Katharine M Raubo Piotr Harrity Joseph P A |
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| Institution: | Department of Chemistry, University of Sheffield, Brook Hill, UK. |
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| Abstract: | reaction: see text] A stepwise formal 3 + 3] cycloaddition sequence via a Grignard addition-cyclization reaction leads to a much improved piperidine synthesis. This methodology provides improved flexibility in both the aziridine substrate and TMM equivalent. |
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