| 盐酸环丙沙星及其制剂含量测定方法的探讨 |
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| 引用本文： | 荆红霞,金明山. 盐酸环丙沙星及其制剂含量测定方法的探讨[J]. 化学分析计量, 2003, 12(4): 42-43 |
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| 作者姓名： | 荆红霞 金明山 |
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| 作者单位： | 浙江京新药业股份有限公司,新昌,312500 |
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| 摘 要： | 非水滴定法测定盐酸环丙沙星的含量时，需要预先加入冰乙酸和乙酸汞进行转化处理，两种试剂的加入顺序对盐酸环丙沙星的溶解速度影响较大，先加入乙酸汞时，盐酸环丙沙星溶解较快。用高效液相色谱法测定盐酸环丙沙星片及盐酸环丙沙星胶囊的含量时，如果以水作溶剂，测定值明显偏低，宜改用0.l mol／L盐酸溶液作溶剂。
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| 关 键 词： | 盐酸环丙沙星 制剂 含量 测定方法 盐酸环丙沙星片 盐酸环丙沙星胶囊 抗菌药品 |
| 修稿时间： | 2003-04-14 |
EXPLORATION OF THE METHODS FOR DETERMINATION OF CIPROFLOXACIN HYDROCHLORIDE AND ITS TABLETS AND CAPSULES |
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| Jing Hongxia,Jin Mingshan. EXPLORATION OF THE METHODS FOR DETERMINATION OF CIPROFLOXACIN HYDROCHLORIDE AND ITS TABLETS AND CAPSULES[J]. Chemical Analysis And Meterage, 2003, 12(4): 42-43 |
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| Authors: | Jing Hongxia Jin Mingshan |
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| Abstract: | Low dissolved speed of ciprofloxacin hydrochloride and great difference between determining value and theoretical value in ciprofloxacin hydrochloride tablets and capsules. The dissolved speed of ciprofloxacin hydrochloride was raised by changing the order of putting in acetic acid and mercuric acetate. The difference between determining value and theoretical value of ciprofloxacin hydrochloride tablets and capsules was reduced by replacing water with 0. 1 mol/L HCl solution, so that the accuracy of inventory is optimized in production. |
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| Keywords: | ciprofloxacin hydrochloride ciprofloxacin hydrochloride tablet ciprofloxacin hydrochloride capsule content determination |
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