| Synthesis of (1H)-3,4-Dihydropyrrolo[2,1-c][1,4]oxazin-1-one Derivatives |
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| 作者姓名： | De Cai FU Hong YU Shou Fang ZHANG* Shenyang Pharmaceutical University Shenyang |
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| 作者单位： | De Cai FU，Hong YU，Shou Fang ZHANG* Shenyang Pharmaceutical University，Shenyang 110016 |
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| 摘 要： | It has been found that some acyl derivatives of 1,2,3,4-tetrahydro-1-indolizin-1-one 1and (1H)-3,4-dihydropyrrolo1,2-a]pyrazin-1-one 2 show remarkable anti-inflammatory and analgesic activities1,2. The interest in extending the study of structure-activity relationships and search of new potent anti-inflammatory and analgesic agents led us to design and synthesize (1H)-3,4-dihydropyrrolo2,1-c]1,4]oxazin-1-one 3 derivatives. NO 1 NNHO2 87654321ONO3 A few examples of the p…
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Synthesis of (1H)-3,4-Dihydropyrrolo[2,1-c][1,4]oxazin-1-one Derivatives |
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| De Cai FU,Hong YU,Shou Fang ZHANG* Shenyang Pharmaceutical University,Shenyang .Synthesis of (1H)-3,4-Dihydropyrrolo[2,1-c][1,4]oxazin-1-one Derivatives[J].Chinese Chemical Letters,2002,13(11). |
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| Authors: | De Cai FU Hong YU Shou Fang ZHANG |
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| Abstract: | In search of new anti-inflammatory and analgesic agents, (1H)-3,4-dihydro- pyrrolo 2,1-c]1,4]oxazin-1-one (3) and its acyl derivatives were designed and prepared. Compound 3 was prepared by treatment of methyl 1-(2-bromoethyl) pyrrole-2-carboxylate with silver oxide and its derivatives were obtained by Friedel-Craftes reaction. Nine of 6-acyl derivatives of compound 3 were prepared. |
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| Keywords: | (1H)-3 4-Dihydropyrrolo[2 1-c][1 4]oxazin-1-one synthesis |
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