Synthesis of series of 1- and 3-differently substituted xanthines from imidazoles |
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Authors: | Hergueta Antonio Rodríguez Figueira María José López Carmen Caamaño Olga Fernández Franco Rodríguez-Borges José Enrique |
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Institution: | Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, Spain. |
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Abstract: | A new and general method is described for the synthesis, in three steps and in good overall yields, of tetrasubstituted xanthines from an easily prepared imidazole precursor. The method is especially useful for the preparation in standardized conditions of series of xanthines combining a broad variety of primary or secondary alkyl, benzyl or aryl groups at N1 and of alkyl or arylmethyl groups at N3, that are not readily available by other methods. |
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