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The synthesis and the structure elucidation of <Emphasis Type="Italic">N,O</Emphasis>-diacetyl derivative of cyclic 3-hydroxymelatonin |
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| Authors: | Aleksandra Siwicka Russel J Reiter Dun X Tian Krystyna Wojtasiewicz Andrezej Leniewski Jan K Maurin Dariusz Błachut Zbigniew Czarnocki |
| Institution: | (1) Faculty of Chemistry, Warsaw University, Pasteur St. 1, 02-093 Warsaw, Poland;(2) Department of Cellular and Structural Biology, University of Texas Health Science Center, 78229 San Antonio, Texas, USA;(3) National Institute of Public Health, Chełmska 30/34, 00-750 Warsaw, Poland;(4) Institute of Atomic Energy, 05-400 Otwock-Świerk, Poland;(5) Department of Criminalistics, Internal Security Agency, 1 Sierpnia 30A, 02-134 Warsaw, Peland |
| Abstract: | Melatonin was subjected to an oxidation to give 3-hydroxymelatonin. All spectroscopic data for this compound were collected. Ab initio calculations for both possible configurations were performed. X-ray data on N,O-diacetyl derivative of 3-hydroxymelatonin allowed the unambigous structure determination. |
| Keywords: | antioxidants alkaloids anti-cancer activity |
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