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Synthesis and hyperthermia property of hydroxyapatite-ferrite hybrid particles by ultrasonic spray pyrolysis |
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| Authors: | Akihiro InukaiNaonori Sakamoto Hiromichi AonoOsamu Sakurai Kazuo ShinozakiHisao Suzuki Naoki Wakiya |
| Affiliation: | a Department of Materials Science and Chemical Engineering, Shizuoka University, 3-5-1 Johoku Naka-ku, Hamamatsu 432-8561, Shizuoka, Japan b Materials Science and Biotechnology, Graduate School of Science and Engineering, Ehime University, 3 Bunkyo-cho, Matsuyama 790-8577, Japan c Department of Metallurgy and Ceramics Science, Tokyo Institute of Technology, 2-12-1 O-okayama Meguro-ku, Tokyo 152-8550, Japan d Graduate School of Materials Science and Technology, Shizuoka University, 3-5-1 Johoku Naka-ku, Hamamatsu 432-8561, Shizuoka, Japan |
| Abstract: | Biocompatible hybrid particles composed of hydroxyapatite (Ca10(PO4)6(OH)2, HAp) and ferrite (γ-Fe2O3 and Fe3O4) were synthesized using a two-step procedure. First, the ferrite particles were synthesized by co-precipitation. Second, the suspension, which was composed of ferrite particles by a co-precipitation method, Ca(NO3)2, and H3PO4 aqueous solution with surfactant, was nebulized into mist ultrasonically. Then the mist was pyrolyzed at 1000 °C to synthesize HAp-ferrite hybrid particles. The molar ratio of Fe ion and HAp was (Fe2+ and Fe3+)/HAp=6. The synthesized hybrid particle was round and dimpled, and the average diameter of a secondary particle was 740 nm. The cross section of the synthesized hybrid particles revealed two phases: HAp and ferrite. The ferrite was coated with HAp. The synthesized hybrid particles show a saturation magnetization of 11.8 emu/g. The net saturation magnetization of the ferrite component was calculated as 32.5 emu/g. The temperature increase in the AC-magnetic field (370 kHz, 1.77 kA/m) was 9 °C with 3.4 g (the ferrite component was 1.0 g). These results show that synthesized hybrid particles are biocompatible and might be useful for magnetic transport and hyperthermia studies. |
| Keywords: | Maghemite Hydroxyapatite Hybrid Core-shell structure Biocompatible Hyperthermia |
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