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Synthesis of Fe3O4 magnetic fluid used for magnetic resonance imaging and hyperthermia |
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| Authors: | YM WangX Cao GH LiuRY Hong YM ChenXF Chen HZ LiB Xu DG Wei |
| Institution: | a College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Organic Synthesis of Jiangsu Province, Soochow University, SIP, Suzhou 215123, China b Resparation Department, the Affiliated Suzhou Municipal Hospital(East-section) of Nanjing Medical University, Suzhou 215001, China c State Key Laboratory of Multiphase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100080, China d Chemical Engineering Department, Chien-shiung Institute of Technology, Suzhou 215411, China e Suzhou Nanotec Inc., Suzhou 215123, China f Center for Nanoscale Systems, School of Engineering and Applied Sciences, Harvard University, 11 Oxford Street, Cambridge, MA 02139, USA |
| Abstract: | Fe3O4 magnetic nanoparticles were prepared by co-precipitation from FeSO4·7H2O and FeCl3·6H2O aqueous solutions using NaOH as precipitating reagent. The nanoparticles have an average size of 12 nm and exhibit superparamagnetism at room temperature. The nanoparticles were used to prepare a water-based magnetic fluid using oleic acid and Tween 80 as surfactants. The stability and magnetic properties of the magnetic fluid were characterized by Gouy magnetic balance. The experimental results imply that the hydrophilic block of Tween 80 can make the Fe3O4 nanoparticles suspending in water stable even after dilution and autoclaving. The magnetic fluid demonstrates excellent stability and fast magneto-temperature response, which can be used both in magnetic resonance imaging and magnetic fluid hyperthermia. |
| Keywords: | Magnetic nanoparticle Magnetic fluid Co-precipitation Hyperthermia Magnetic resonance imaging |
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