Magnetic and in vitro heating properties of implants formed in situ from injectable formulations and containing superparamagnetic iron oxide nanoparticles (SPIONs) embedded in silica microparticles for magnetically induced local hyperthermia |
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Authors: | Pol-Edern Le Renard Rolf LortzCarmine Senatore Jean-Philippe RapinFranz Buchegger Alke Petri-FinkHeinrich Hofmann Eric DoelkerOlivier Jordan |
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Affiliation: | a School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland b Department of Physics, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong c Department of Condensed Matter Physics and MaNEP/NCCR, University of Geneva, Geneva, Switzerland d Laboratory of Crystallography, University of Geneva, Geneva, Switzerland e Service of Nuclear Medicine, University Hospital of Lausanne, Lausanne, University Hospital of Geneva, Geneva, Switzerland f Department of Chemistry, University of Fribourg, Fribourg, Switzerland g Laboratory for Powder Technology, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland |
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Abstract: | The biological and therapeutic responses to hyperthermia, when it is envisaged as an anti-tumor treatment modality, are complex and variable. Heat delivery plays a critical role and is counteracted by more or less efficient body cooling, which is largely mediated by blood flow. In the case of magnetically mediated modality, the delivery of the magnetic particles, most often superparamagnetic iron oxide nanoparticles (SPIONs), is also critically involved. We focus here on the magnetic characterization of two injectable formulations able to gel in situ and entrap silica microparticles embedding SPIONs. These formulations have previously shown suitable syringeability and intratumoral distribution in vivo. The first formulation is based on alginate, and the second on a poly(ethylene-co-vinyl alcohol) (EVAL). Here we investigated the magnetic properties and heating capacities in an alternating magnetic field (141 kHz, 12 mT) for implants with increasing concentrations of magnetic microparticles. We found that the magnetic properties of the magnetic microparticles were preserved using the formulation and in the wet implant at 37 °C, as in vivo. Using two orthogonal methods, a common SLP (20 W g−1) was found after weighting by magnetic microparticle fraction, suggesting that both formulations are able to properly carry the magnetic microparticles in situ while preserving their magnetic properties and heating capacities. |
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Keywords: | Magnetically mediated hyperthermia Superparamagnetism SPIONS Microparticles Composite magnetic microparticles Injectable formulations In situ forming implant Magnetic properties SQUID Heating AMF Specific power loss Calorimetry Pycnometry Laser diffraction DFX TEM SEM |
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