The use of a linear Halbach array combined with a step-SPLITT channel for continuous sorting of magnetic species |
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Authors: | Hoyos Mauricio Moore Lee Williams P Stephen Zborowski Maciej |
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Affiliation: | a Laboratoire de Physique et Mécanique des Milieux Hétérogènes, ESPCI, Paris 75005, France b Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA |
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Abstract: | The Quadrupole Magnetic Sorter (QMS), employing an annular flow channel concentric with the aperture of a quadrupole magnet, is well established for cell and particle separations. Here we propose a magnetic particle separator comprising a linear array of cylindrical magnets, analogous to the array proposed by Klaus Halbach, mated to a substantially improved form of a parallel plate SPLITT channel, known as the step-SPLITT channel. While the magnetic force and throughput are generally lower than for the QMS, the new separator has advantages in ease of fabrication and the ability to vary the magnetic force to suit the separands. Preliminary experiments yield results consistent with prediction and show promise regarding future separations of cells of biomedical interest. |
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Keywords: | Magnetic separation Particle fractionation SPLITT step-SPLITT |
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