Asymmetric catalytic synthesis of enantiopure N-protected 1,2-amino alcohols |
| |
Authors: | Bartoli Giuseppe Bosco Marcella Carlone Armando Locatelli Manuela Melchiorre Paolo Sambri Letizia |
| |
Institution: | Department of Organic Chemistry A. Mangini, University of Bologna v.le Risorgimento 4, 40136 Bologna, Italy. giuseppe.bartoli@unibo.it |
| |
Abstract: | reaction: see text] The asymmetric aminolytic kinetic resolution (AKR) of racemic terminal epoxides using carbamates as the nucleophile catalyzed by (salen)Co(III) complex provides a practical and straightforward method for the synthesis of both aliphatic and aromatic N-Boc- or N-Cbz-protected 1,2-amino alcohols in almost enantiomerically pure form (ee >/= 99%). The AKR uses an easily accessible catalyst and inexpensive starting materials, and the reactions are conveniently carried out at room temperature under an air atmosphere. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|