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Synthetic polymers for simultaneous bacterial sequestration and quorum sense interference |
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| Authors: | Xue Xuan Pasparakis George Halliday Nigel Winzer Klaus Howdle Steven M Cramphorn Christopher J Cameron Neil R Gardner Paul M Davis Benjamin G Fernández-Trillo Francisco Alexander Cameron |
| Affiliation: | School of Pharmacy, The University of Nottingham, University Park, Nottingham NG7 2RD (UK). |
| Abstract: | Double agents: Dual-action polymers are able to sequester rapidly the marine organism Vibrio harveyi from suspension, while at the same time quenching bacterial quorum sense (QS) signals. The potency of the polymers is assessed by cell aggregation experiments and competitive binding assays against a QS signal precursor, and their effect on bacterial behavior is shown by means of bioluminescence. |
| Keywords: | cell adhesion luminescence polymers quorum sensing therapeutics |
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