Gastroprotective activity of epitaondiol and sargaol |
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Authors: | Areche Carlos San-Martín Aurelio Rovirosa Juana Sepúlveda Beatriz |
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Institution: | Departamento de Química, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile. areche@uchile.cl |
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Abstract: | The effects of epitaondiol (1) and sargaol (2), isolated from the brown alga Stypopodium flabelliforme on HCl/ethanol-induced gastric lesions in mice were evaluated and compared with that of lansoprazole. Epitaondiol and sargaol (6.25 - 50 mg/kg) dose-dependently inhibited the appearance of gastric lesions in mice, displaying similar values to lansoprazole at 20 mg/kg. Both epitaondiol and sargaol showed gastroprotective activity with ED50 values of 40 mg/kg and 35 mg/kg, respectively. The results suggest that epitaondiol and sargaol protect the gastric mucosa in the HCl/EtOH model in mice. |
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