Enantioselective Titanium(III)-Catalyzed Reductive Cyclization of Ketonitriles |
| |
| Authors: | Jan Streuff Markus Feurer Plamen Bichovski Georg Frey Urs Gellrich |
| |
| Institution: | Institut für Organische Chemie und Biochemie, Albert‐Ludwigs‐Universit?t Freiburg, Albertstrasse 21, 79104 Freiburg (Germany) http://portal.uni‐freiburg.de/streuff |
| |
| Abstract: | Reduction, please! The title reaction affords α-hydroxyketones, a common structural motif in biologically active natural products, in good yields and high enantioselectivities at room temperature. The commercially available ansa-titanocene 1 was found to be an efficient catalyst for this process, which presumably proceeds by addition of a ketyl radical to a nitrile. |
| |
| Keywords: | asymmetric catalysis cyclization radical reactions reduction titanium |
| 本文献已被 PubMed 等数据库收录！ |
|
