Live cell imaging of lysosomal pH changes with pH responsive ratiometric lanthanide probes |
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| Authors: | David G Smith Brian K McMahon Robert Pal David Parker |
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| Affiliation: | Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK. david.parker@dur.ac.uk. |
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| Abstract: | Europium and terbium complexes of two structurally related ligands have been evaluated as optical probes to monitor changes in lysosomal pH; calibration using ionophores and fluorescent probes allows monitoring of the time dependence of lysosomal pH change, examining the green/red intensity ratio from internalised Tb-Eu complexes. |
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