| 3,4-二氢-1-(4-哌啶基)-2(1H)-喹啉酮的合成 |
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| 引用本文： | 陆文超,李瑛琦,郭春,周凯. 3,4-二氢-1-(4-哌啶基)-2(1H)-喹啉酮的合成[J]. 合成化学, 2004, 12(4): 397-398,404,J005 |
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| 作者姓名： | 陆文超 李瑛琦 郭春 周凯 |
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| 作者单位： | 沈阳药科大学,辽宁,沈阳,110016;东北制药总厂,辽宁,沈阳,110024 |
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| 摘 要： | 以苄胺为原料，经6步反应得到新型抗高血压药OPC-21268的中间体3，4-二氢-1-(4-哌啶基)-2(1H)-喹啉酮，总收率13．9％．
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| 关 键 词： | 3 4-二氢-1-(4-哌啶基)-2(1H)-喹啉酮 1-苄基-4-哌啶酮 苄胺 合成 |
| 文章编号： | 1005-1511(2004)04-0397-02 |
Synthesis of 3,4-Dihydro-1-(4-piperidyl)-2(1H)-quinolinone |
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| LU Wen-chao ,LI Ying-qi ,GUO Chun ,ZHOU Kai. Synthesis of 3,4-Dihydro-1-(4-piperidyl)-2(1H)-quinolinone[J]. Chinese Journal of Synthetic Chemistry, 2004, 12(4): 397-398,404,J005 |
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| Authors: | LU Wen-chao LI Ying-qi GUO Chun ZHOU Kai |
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| Affiliation: | LU Wen-chao 1,LI Ying-qi 1,GUO Chun 1,ZHOU Kai 2 |
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| Abstract: | The intermediate of new anti-hypertension drug OPC-21268, 3,4-dihydro-1-(4-piperidyl)-2(1H)-quinolinone, was synthesized from benzyl amine through six steps. The total yield is 13.9%. |
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| Keywords: | dihydro-1-(4-piperidyl)-2(1H)-quinolinone 1-benzyl-4-piperidones benzyl amine synthesis |
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