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Total synthesis of matlystatin A |
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| Authors: | Kazuhiko Tamaki Shinwa Kurihara Yukio Sugimura |
| Affiliation: | Bioscience Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi 1-chome, Shinagawa-ku, Tokyo 140, Japan |
| Abstract: | Of the five congeners in the matlystatin series, matlystatin A (1) is the most potent inhibitor of type IV collagenases. The total synthesis of 1 was accomplished, and the absolute configuration was unambiguously determined as shown in figure I. |
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