Transient binding and dissipation in cross-linked actin networks |
| |
Authors: | Lieleg O Claessens M M A E Luan Y Bausch A R |
| |
Affiliation: | Lehrstuhl für Biophysik E27, Technische Universit?t München, Germany. |
| |
Abstract: | In contrast with entangled actin solutions, transiently cross-linked actin networks can provide highly elastic properties while still allowing for local rearrangements in the microstructure-on biological relevant time scales. Here, we show that thermal unbinding of transient cross-links entails local stress relaxation and energy dissipation in an intermediate elasticity dominated frequency regime. We quantify the viscoelastic response of an isotropically cross-linked actin network by experimentally tuning the off rate of the transiently cross-linking molecules, their density, and the solvent viscosity. We reproduce the measured frequency response by a semiphenomenological model that is predicated on microscopic unbinding events. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|