First biosynthetic evidence on the phenyl-containing polyketides of the marine mollusc Scaphander lignarius |
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Authors: | Cutignano Adele Avila Conxita Domenech-Coll Anna d'Ippolito Giuliana Cimino Guido Fontana Angelo |
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Institution: | Instituto di Chimica Biomolecolare, CNR, Pozzuoli, Naples, italy. |
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Abstract: | The biosynthesis of lignarenones 1 and 2, the major polyketides of the Mediterranean mollusc Scaphander lignarius is described. The process is primed by benzoic acid and requires acetate and propionate as extender units. The labeling pattern suggests PKS-like synthesis of an unusual E,Z,E-triene chain and origin of the benzoate unit from phenylalanine. 13C-13C NMR COSY has been used to establish the labeling positions due to incorporation of 13C2-acetate. |
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