Copper-mediated and copper-catalyzed cross-coupling of indoles and 1,3-azoles: double C-H activation |
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| Authors: | Nishino Mayuko Hirano Koji Satoh Tetsuya Miura Masahiro |
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| Affiliation: | Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Japan. |
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| Abstract: | A new bronze age: the described copper-mediated cross-coupling with double C-H activation can provide a convergent access to indole-containing biheteroaryls that are of high interest in pharmaceutical and medicinal chemistry. In this strategy an easily attachable and detachable 2-pyrimidyl directing group is used. Moreover, a variant that is catalytic in copper is achieved by using atmospheric oxygen as an ideal co-oxidant. |
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| Keywords: | C?H activation copper cross‐coupling indoles synthetic methods |
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